{"id":547142,"date":"2026-06-01T12:23:13","date_gmt":"2026-06-01T04:23:13","guid":{"rendered":"https:\/\/www.um.edu.mo\/news-and-press-releases\/campus-news\/detail\/64117-2\/"},"modified":"2026-06-01T12:23:13","modified_gmt":"2026-06-01T04:23:13","slug":"64117","status":"publish","type":"post","link":"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/campus-news\/detail\/64117\/","title":{"rendered":"UM research team develops novel antibody-conjugated drug for targeted breast cancer treatment"},"content":{"rendered":"\n                        \n                        <p>A research team led by Zhao Qi, associate professor\nin the Faculty of Health Sciences (FHS) at the University of Macau (UM), has\nmade significant progress in targeted cancer immunotherapy. The team has developed\na novel type of antibody-engineered lipid nanoparticles (LNPs). These smart\nnanoparticles can deliver chemotherapy drugs precisely to the tumour site,\nwhile also reprogramming tumour cell metabolism to reverse the\nimmunosuppressive tumour microenvironment and activate the body\u2019s immune system\nto kill tumour cells. The research has been published in the international\njournal <i>Advanced Science<\/i>.<\/p><p>Triple-negative breast cancer (TNBC) is widely\nregarded as the most malignant subtype of breast cancer. Currently,\nchemotherapy remains the cornerstone of its treatment. However, conventional chemotherapeutic\nagents lack specificity, often causing severe toxic side effects in normal\ntissues while killing tumour cells. Furthermore, monotherapy with chemotherapy cannot\ncompletely eradicate tumour cells, and often leads to tumour recurrence and metastasis.\nIn recent years, combining chemotherapy with immunotherapy has emerged as a\npromising new approach. This approach aims to kill tumour cells with drugs while\nactivating the patient\u2019s own immune system (especially T lymphocytes) to\nidentify and eliminate residual cancer cells. However, tumour cells create an\nimmunosuppressive tumour microenvironment (TME) by overexpressing immune\ncheckpoint proteins such as PD-L1 and secreting immunosuppressive factors such\nas TGF-<i>\u03b2<\/i>1. This depletes T cell function and leads to a poor immune\nresponse.<\/p><p>To address the challenges associated with targeted\ndrug delivery and immunosuppression, the research team designed and fabricated\na multifunctional LNP called Lip(MA+Met)-R1. It has two advantages:<\/p><p>(1) Precise navigation and visualisation: The LNP\nsurface is conjugated to a human receptor tyrosine kinase-like orphan receptor\n1 antibody (ROR1 Ab) via an acid-labile linker. This enables the LNPs to target\nand accumulate in tumour tissues. Meanwhile, the lipid bilayer incorporates a\nsecond near-infrared (NIR-II, 1000-1700 nm) fluorescence probe, enabling\nhigh-resolution, real-time fluorescence imaging of deep-seated tumours, and providing\ndirection for precision treatment.<\/p><p>(2) Dual payload and synergistic treatment: The LNPs\nencapsulate two types of \u2018ammunition\u2019, a chemotherapeutic drug and an immunoadjuvant.\nThe chemotherapeutic drug is monomethyl auristatin E (MA), a cytotoxic agent which\ninhibits microtubule function in tumour cells, leading to cell division arrest\nand apoptosis. The immunomodulatory drug is metformin (Met), a commonly used\nclinical drug which activates AMPK protein phosphorylation by inhibiting\nmitochondrial oxidative phosphorylation (OXPHOS) in tumour cells. This process results\nin abnormal glycosylation and degradation of the PD-L1 protein, thereby\ndownregulating PD-L1 expression in the cell membrane and cytoplasm and reducing\nthe secretion of TGF-<i>\u03b2<\/i>1. This fundamentally reverses the\nimmunosuppressive TME and enhances the immune response.<\/p><p>The first author of this study is Dai Yeneng, research\nassistant professor in FHS. The corresponding authors are Prof Zhao and Zhu Lipeng,\nlecturer in the School of Life Sciences at Central South University. The\nproject was funded by the Science and Technology Development Fund of the Macao\nSAR (Grant Nos.: 0150\/2025\/AFJ, 0009\/2023\/RIC, and 0065\/2025\/ITP1), the\nUniversity of Macau (Grant Nos.: MYRG2022-00143-FHS and\nMYRG-GRG2023-00158-FHS-UMDF), and the Natural Science Foundation of Guangdong\nProvince (Grant No.: 2023A1515010549). The full article is available at: <a href=\"https:\/\/doi.org\/10.1002\/advs.202518468\">https:\/\/doi.org\/10.1002\/advs.202518468<\/a><\/p><div><\/div><div><\/div><div><table style=\"width: 44.7597%;height: 201px\"><tbody><tr style=\"height: 21px\"><td style=\"height: 21px;width: 100.095%\" colspan=\"2\">Source: Faculty of Health Sciences<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"><\/td> <td style=\"height: 21px;width: 43.7669%\"><\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 100.095%\" colspan=\"2\">Media Contact Information:<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 12px;width: 100.095%\" colspan=\"2\">Communications Office, University of Macau<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Albee Lei<\/td> <td style=\"height: 21px;width: 43.7669%\">Tel: (853) 8822 8004<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Bell Leong<\/td> <td style=\"height: 21px;width: 43.7669%\">Tel: (853) 8822 8009<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Email:<\/td> <td style=\"height: 21px;width: 43.7669%\"><a href=\"mailto:prs.media@um.edu.mo\">prs.media@um.edu.mo<\/a><\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"><\/td> <td style=\"height: 21px;width: 43.7669%\"><\/td><\/tr><\/tbody><\/table><\/div>\n\n\n                        \n                        ","protected":false},"excerpt":{"rendered":"<p>A research team led by Zhao Qi, associate professor in the Faculty of Health Sciences (FHS) at the University of Macau (UM), has made significant progress in targeted cancer immunotherapy&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":547145,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[59],"tags":[],"class_list":["post-547142","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>UM research team develops novel antibody-conjugated drug for targeted breast cancer treatment | Universidade de Macau<\/title>\n<meta name=\"description\" content=\"Universidade de Macau: Uma universidade abrangente p\u00fablica de n\u00edvel internacional fundada em 1981\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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