{"id":47408,"date":"2017-11-20T12:15:00","date_gmt":"2017-11-20T12:15:00","guid":{"rendered":"https:\/\/www.um.edu.mo\/news-and-press-releases\/press-release\/2017\/11\/43670-pt_pt\/"},"modified":"2017-11-20T12:15:00","modified_gmt":"2017-11-20T12:15:00","slug":"43670","status":"publish","type":"post","link":"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/press-release\/detail\/43670\/","title":{"rendered":"O que s\u00e3o antibi\u00f3ticos ecol\u00f3gicos? Outro avan\u00e7o conseguido pelas equipas de investiga\u00e7\u00e3o da UM"},"content":{"rendered":"\n                        \n                        <p>Research\nteams from the University of Macau (UM) recently developed an eco-friendly\nantibiotic. Currently, antibiotics are being discharged irresponsibly by\npharmaceutical manufacturing plants and hospitals, which has led to the\ndevelopment and spread of antibiotic resistant bacteria. The research study\naims to address this problem by developing a new type of antibiotics. The\nrelated paper has been published in<i>\nChemical Communications<\/i>, a prestigious international journal in the field\npublished by the Royal Society of Chemistry.&nbsp;<\/p><p>It has been\nsuggested that irresponsible antibiotics discharge from pharmaceutical\nmanufacturers is one of the main reasons why antibiotic resistant bacteria are\nspreading in many countries. Large quantities of antibiotics have been\ndischarged by manufacturing plants into the environment without further\nprocessing or deactivation. While governments around the world should enforce\ntighter control of manufacturing plants in this respect, scientists from UM\nhave conducted a research study to explore the possibility of stemming\nenvironment pollution once for all through activatable antibiotics. The study\nwas jointly conducted by a research team led by Dr Wang Ruibing from the\nInstitute of Chinese Medical Sciences and another research team led by Dr Zheng\nJun from the Faculty of Health Sciences. Their antibiotic includes an\n\u2018antibiotic precursor\u2019 and an \u2018activator\u2019 . The antibiotic precursor\nitself does not have any antibacterial activity and therefore will not promote\nantibiotic resistance even if discharged into the environment. For this reason,\nthe teams name their antibiotic \u2018eco-friendly antibiotic\u2019. However, the\nantibiotic precursor can be formulated into an active antibiotic with a simple\nmixing procedure either before or during administration.<\/p><p>\n\n\n\n\n\n\n\nIn the research study, as a\nproof of concept, a low molecular weight polycation polyethylenimine (PEI) was\ndesigned as the inactive antibacterial precursor. CB[8] (self-inert, no\nantibacterial activity, chemically called supramolecular crosslinker), was used\nas the activator to crosslink PEI, and precisely tune its activity. Moreover,\nthe activated antibiotic can be de-activated by a simple addition of the\nde-activator. This design was validated by using four different bacterial\nstrains, and the mechanism of this design is that hyperbranched high-molecular-weight\npolycations may offer more cationic groups as a crosslinked network to interact\nwith the phospholipids of bacteria via its rearrangement. For more information\nabout the research article, please visit: <a href=\"http:\/\/pubs.rsc.org\/-\/content\/articlehtml\/2017\/cc\/c7cc02466e\">http:\/\/pubs.rsc.org\/-\/content\/articlehtml\/2017\/cc\/c7cc02466e<\/a><\/p><div><\/div><div><\/div><div><\/div><div><div><div>Source:&nbsp;Faculty of Health Sciences<\/div><div><\/div><div>Media Contact Information:<\/div><div>Communications Office, University of Macau<\/div><div><\/div><div>Albee Lei&nbsp; Tel\uff1a(853) 88228004<\/div><div>Kelvin U&nbsp; Tel\uff1a(853) 88224322<\/div><div>Email\uff1aprs.media@um.edu.mo<\/div><p><\/p><p><\/p><p><\/p><div>UM Website\uff1awww.umac.mo<\/div><\/div><\/div><p><\/p>\n                        \n                        ","protected":false},"excerpt":{"rendered":"<p>Research teams from the University of Macau (UM) recently developed an eco-friendly antibiotic. Currently, antibiotics are being discharged irresponsibly by pharmaceutical manufacturing plants and hospitals, which has led to the&#8230;<\/p>\n","protected":false},"author":1,"featured_media":47409,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[60],"tags":[],"class_list":["post-47408","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>O que s\u00e3o antibi\u00f3ticos ecol\u00f3gicos? 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Outro avan\u00e7o conseguido pelas equipas de investiga\u00e7\u00e3o da UM | Universidade de Macau\" \/>\n<meta property=\"og:description\" content=\"Universidade de Macau: Uma universidade abrangente p\u00fablica de n\u00edvel internacional fundada em 1981\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/press-release\/detail\/43670\/\" \/>\n<meta property=\"og:site_name\" content=\"Universidade de Macau\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/universityofmacau\" \/>\n<meta property=\"article:published_time\" content=\"2017-11-20T12:15:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.um.edu.mo\/wp-content\/uploads\/2020\/10\/47408-1_resized-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"web_admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UM_1981\" \/>\n<meta name=\"twitter:site\" content=\"@UM_1981\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"web_admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo estimado de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/press-release\/detail\/43670\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/press-release\/detail\/43670\/\"},\"author\":{\"name\":\"web_admin\",\"@id\":\"https:\/\/www.um.edu.mo\/pt-pt\/#\/schema\/person\/bfdcd3a75d1b778a93663e5dee2e33bb\"},\"headline\":\"O que s\u00e3o antibi\u00f3ticos ecol\u00f3gicos? 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