{"id":398515,"date":"2025-05-12T17:57:58","date_gmt":"2025-05-12T09:57:58","guid":{"rendered":"https:\/\/www.um.edu.mo\/news-and-press-releases\/press-release\/detail\/61121-2\/"},"modified":"2025-05-13T16:26:11","modified_gmt":"2025-05-13T08:26:11","slug":"61121","status":"publish","type":"post","link":"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/press-release\/detail\/61121\/","title":{"rendered":"Equipa de investiga\u00e7\u00e3o da UM fez novos progressos no tratamento da fibrose pulmonar"},"content":{"rendered":"\n                        \n                        <p><\/p><p>A research team led by Zheng Ying, professor in the\nInstitute of Chinese Medical Sciences (ICMS) and Liu Tzu-Ming, associate professor\nin the Faculty of Health Sciences at the University of Macau (UM), has\ndeveloped a highly efficient aerosol\ninhalation system. The system can promote lung tissue repair and effectively\nblock fibrogenic signalling pathways, providing an innovative strategy for the clinical\ntreatment of pulmonary fibrosis. The research has been published in the\nprestigious interdisciplinary journal <i>Science\nAdvances<\/i>.<\/p>\n\n<p>&nbsp;<\/p>\n\n<p>Pulmonary fibrosis (PF) is a chronic, progressive, and\nfatal interstitial lung disease with limited therapeutic options. Recent\nadvancements in pulmonary gene therapy have shown the potential to halt or even\nreverse PF, particularly by focusing on correcting gene mutations in alveolar\nepithelial cells. Although gene therapies targeting alveolar epithelial cells\nhave shown potential, their clinical application remains limited by technical\nbottlenecks in pulmonary delivery systems. To overcome these barriers, the\nresearch team developed an aerosol inhalation system that integrates three\ncomponents: (1) a vibrating mesh nebuliser to aerosolise lipid nanoparticles\n(LNPs); (2) a hydrogen supplement system that exploits the low viscosity and\nanti-inflammatory properties of hydrogen to enhance mucus penetration; (3) a\ncontrolled dosing chamber to enable precise therapeutic delivery. The study\nhypothesised that hydrogen\u2019s unique physicochemical properties (such as lower Reynolds\nnumbers) could improve alveolar deposition and alleviate oxidative stress.<\/p>\n\n<p>&nbsp;<\/p>\n\n<p>Rather than targeting epithelial cells, this strategy\nfocused on profibrotic alveolar macrophages (AMs), which drive PF progression\nvia TGF\u03b21 secretion. The team developed a hybrid lipid nanoparticle (HNP) by\ncombining T cell apoptotic body membranes with pH-responsive DOP-DEDA lipids, allowing\nmacrophage-specific targeting and enhanced endosomal escape. These HNPs\ndelivered TGF\u03b21 siRNA to macrophages, suppressing fibrotic signalling while\nstimulating hepatocyte growth factor (HGF) production to promote lung tissue repair.\nThe hydrogen-nebulised HNPs demonstrated stability during nebulisation and\neffectively penetrated the mucus barrier through laminar flow-assisted positive\npressure. This approach not only blocks fibrotic pathways but also reprogrammes\nmacrophage phenotypes, modulating the lung microenvironment to achieve\nsustained therapeutic effects. By integrating hydrogen gas with hybrid LNPs,\nthe study presents a dual-action therapy that addresses both the delivery\nchallenges and disease mechanisms of PF, offering a promising avenue for\nlong-term treatment.<\/p>\n\n<p>&nbsp;<\/p>\n\n<p>The corresponding author of the study is Prof Zheng\nYing, with Prof Liu Tzu-Ming as co-corresponding author. The first author is Liu\nChang, a PhD graduate in ICMS. The research was supported by the Science and\nTechnology Development Fund of the Macao SAR (File No: <a name=\"_Hlk192595017\">005\/2023\/SKL,\n0086\/2021\/A2, 0003\/2023\/RIC, 0013\/2023\/RIC<\/a>), <a name=\"_Hlk192595048\">UM\n(File No: MYRG-GRG2023-00159-ICMS-UMDF, MYRG-CRG2022-00009-FHS<\/a>), NMPA Key\nLaboratory for Quality Control and Evaluation of Pharmaceutical Excipients and Guangdong\nInstitute for Drug Control (File No: <a name=\"_Hlk192595206\">KF2022015<\/a>).\nThe full text of the study is available at: <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adt2752\">https:\/\/www.science.org\/doi\/10.1126\/sciadv.adt2752<\/a>.<\/p>\n\n<p>&nbsp;<\/p><p><\/p>\n\n<table style=\"width: 44.7597%;height: 201px\"> <tbody> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 100.095%\" colspan=\"2\">Source: Institute of Chinese Medical Sciences<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 100.095%\" colspan=\"2\">Media Contact Information:<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 12px;width: 100.095%\" colspan=\"2\">Communications Office, University of Macau<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Albee Lei<\/td> <td style=\"height: 21px;width: 43.7669%\">Tel: (853) 8822 8004<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Bell Leong<\/td> <td style=\"height: 21px;width: 43.7669%\">Tel: (853) 8822 8009<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Email:<\/td> <td style=\"height: 21px;width: 43.7669%\"><a href=\"mailto:prs.media@um.edu.mo\">prs.media@um.edu.mo<\/a><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"><\/td><td style=\"height: 21px;width: 43.7669%\"><\/td><\/tr>\n<\/tbody>\n<\/table>\n                        \n                        ","protected":false},"excerpt":{"rendered":"<p>A research team led by Zheng Ying, professor in the Institute of Chinese Medical Sciences (ICMS) and Liu Tzu-Ming, associate professor in the Faculty of Health Sciences at the University&#8230;<\/p>\n","protected":false},"author":1,"featured_media":398821,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[60],"tags":[],"class_list":["post-398515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Equipa de investiga\u00e7\u00e3o da UM fez novos progressos no tratamento da fibrose pulmonar | Universidade de Macau<\/title>\n<meta name=\"description\" content=\"Universidade de Macau: Uma universidade abrangente p\u00fablica de n\u00edvel internacional fundada em 1981\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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