A\nresearch team from the Faculty of Health Sciences (FHS), University of Macau\n(UM), has developed a new method to treat skin wounds with stem\ncell spheres via topical application. Compared with the traditional method of stem cell\ninjection, this new method is non-invasive and efficient. The study has been\npublished in the renowned journal Theranostics<\/i> (impact factor 8.063).<\/p>
Titled \u2018Noninvasive\nApplication of Mesenchymal Stem Cell Spheres Derived from hESC Accelerates Wound\nHealing in a CXCL12-CXCR4 Axis-dependent Manner\u2019, the study was conducted by Prof\nXu Ren-He from the FHS, along with his PhD students Wang Xiaoyan, Jiang Bin and\nZheng Dejin as well as research assistant Dr Li Enqin. Dr Sun Huiyan, an\nassistant professor from Jilin University School of Artificial Intelligence\nprovided bioinformatic analysis.<\/p>
The team\nhas found that mesenchymal stem cells (MSC) spheres can be directly applied to\nskin wounds. Even in hypoxic and inflammatory environments of the wound, the\nstem cell spheres can survive much better than dissociated cells and penetrate\nquickly into the wound to help with epidermal and vascular regeneration.\nCompared with the traditional method of stem cell injection, this new method\ngreatly improves the survival rate of transplanted cells, and the topical\napplication of the stem cell spheres reduces the pain of the transplantation\nprocess. Instead of using MSCs from traditional somatic sources such as bone\nmarrow, adipose and umbilical cord, this study used MSCs differentiated continuously\nfrom human embryonic stem cells (hESCs) in an incubator to overcome the\nlimitations of MSC sources. The hESC-derived MSCs have higher viability and better\nfunctions than MSCs derived from somatic sources.<\/p>
At\npresent, the delivery of stem cells mainly relies on intravenous or local injections.\nThese methods cause inconvenience and pain to the patients. Moreover, the\ninjected cells have low vitality and hardly play the expected role. In this\nstudy, stem cells are directly dropped onto the wound in the form of spheres, which\nare visible in the early stage. They can then rapidly migrate to underneath the\nwound and recruit epidermal cells on the edges of the wound to expand and\nmigrate towards the centre. This new technology is convenient, safe, and\nefficient.<\/p>
Combined\nwith the characteristics of spheroid cell storage and transport under ambient\nconditions, it is expected to provide a new way for skin wound treatment. In\norder to improve the biosafety of the method and eliminate the tumorigenic\nconcern of stem cells, the researchers inserted a suicide gene into the stem\ncell genome, which can kill the remaining stem cells and their derivatives\nafter the therapy by injecting a small chemical drug that triggers the\nexpression of the suicide gene.<\/p>
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This\nproject was funded by UM and the Macao Science and Technology Development Fund.\nA patent application for the technology has been filed. For more information, please\nvisit www.thno.org\/v09p6112.htm.<\/p>
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Source: Faculty of Health Sciences<\/p>
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Media Contact Information:Communications Office, University of Macau<\/p>
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Albee Lei Tel\uff1a(853) 88228004Kelvin U Tel\uff1a(853) 88224322Email\uff1aprs.media@um.edu.moUM Website\uff1awww.um.edu.mo<\/p>
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A research team from the Faculty of Health Sciences (FHS), University of Macau (UM), has developed a new method to treat skin wounds with stem cell spheres via topical application….<\/p>\n","protected":false},"author":1,"featured_media":37231,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[60],"tags":[],"class_list":["post-37230","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release"],"acf":[],"yoast_head":"\n