{"id":346034,"date":"2024-07-05T14:45:53","date_gmt":"2024-07-05T06:45:53","guid":{"rendered":"https:\/\/www.um.edu.mo\/news-and-press-releases\/campus-news\/detail\/58597-2\/"},"modified":"2024-07-08T15:33:52","modified_gmt":"2024-07-08T07:33:52","slug":"58597","status":"publish","type":"post","link":"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/campus-news\/detail\/58597\/","title":{"rendered":"UM desenvolve nova formula\u00e7\u00e3o oral para a colite ulcerosa"},"content":{"rendered":"\n \n

A research team led by Wang Ruibing, professor at the\nInstitute of Chinese Medical Sciences (ICMS) at the University of Macau (UM), has\ndeveloped a novel oral formulation for the targeted therapy of ulcerative\ncolitis. The research results have been published in the prestigious international\njournal Science Advances<\/i>.<\/p>\n\n

Ulcerative colitis, a type of inflammatory bowel\ndisease, is a common inflammatory disease of the gastrointestinal tract. Although\noral anti-inflammatory medications are the preferred method for patients, clinical\noutcomes are often unsatisfactory due to challenges including poor drug\naccumulation, limited penetration of mucus barrier, and insufficient\nelimination of reactive oxygen species (ROS) and inflammatory cytokines.\nTherefore, it is critical to develop an oral formulation that can effectively\npenetrate the mucus barrier, accumulate in inflamed tissue, and eliminate\ninflammatory factors and ROS.<\/p>\n\n

The research team had previously developed macrophage-based\nnanodrugs and macrophage sponges for the targeted therapy of inflammatory\ndiseases such as atherosclerosis and acute pneumonia, and had published two\nresearch articles in Nature\nCommunications<\/i>. However, both of them are injectable formulations that are\nnot suitable for oral administration to treat intestinal inflammation and are unable\nto actively penetrate the mucus barrier.<\/p>\n\n

Building on the previous research, the research team\nthen developed an oral medication that does not contain small-molecule drugs. This\nformulation uses asymmetric M2 macrophage membrane-coated Janus nanomotors (M2\nmacrophage-biomimetic nanorobots) embedded in sodium alginate hydrogel\nmicrospheres. The sodium alginate microspheres ensure the stability of the nanomotors\nin the harsh gastric environment and release them into the intestinal tract.\nThe M2 macrophage membrane enhances the delivery efficiency of the nanomotors\nto the inflammatory colon and acts as a nanosponge to effectively neutralise\ninflammatory factors. Additionally, the propelling force of oxygen generated by\nthe catalytic consumption of hydrogen peroxide facilitates the penetration of\nnanomotors through the colonic mucus barrier into inflammatory tissues. This\nprocess eliminates ROS, alleviates tissue hypoxia, polarises macrophages, and\nreduces colonic epithelial cell apoptosis.<\/p>\n\n

The research is published in the prestigious journal Science Advances<\/i> under the title \u2018Oral\nmicrosphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted\ntherapy of ulcerative colitis\u2019. Prof Wang is the corresponding author, and Gao\nCheng, research assistant professor at ICMS, is the co-corresponding author. UM\nPhD candidate Luo Ruifeng, MPhil student Liu Jinwei, and Cheng Qian, PhD graduate\nof UM and associate professor at Chengdu University of Traditional Chinese\nMedicine, are the co-first authors. The research project was funded by the\nScience and Technology Development Fund of the Macao SAR (File No: 0047\/2023\/AMJ,\n0086\/2022\/A2, 005\/2023\/SKL, 0001\/2023\/RIA1, 0070\/2023\/RIA2, and 0006\/2022\/ITP)\nand UM (File No: MYRG2022-00081-ICMS). The full version of the research article\nis available at https:\/\/www.science.org\/doi\/10.1126\/sciadv.ado6798<\/a>.<\/p>\n\n

 <\/p>
Source: Institute of Chinese Medical Sciences<\/td><\/tr>
<\/td><\/td><\/tr>
Media Contact Information:<\/td><\/tr>
Communications Office, University of Macau<\/td><\/tr>
<\/td><\/td><\/tr>
Albee Lei<\/td>Tel: (853) 8822 8004<\/td><\/tr>
Cravina Chong<\/td>Tel: (853) 8822 4323<\/td><\/tr>
Email:<\/td>prs.media@um.edu.mo<\/a><\/td><\/tr>
<\/td><\/td><\/tr>
<\/td><\/tr><\/tbody><\/table>\n \n ","protected":false},"excerpt":{"rendered":"

A research team led by Wang Ruibing, professor at the Institute of Chinese Medical Sciences (ICMS) at the University of Macau (UM), has developed a novel oral formulation for the…<\/p>\n","protected":false},"author":1,"featured_media":346111,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[61],"tags":[],"class_list":["post-346034","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news"],"acf":[],"yoast_head":"\nUM desenvolve nova formula\u00e7\u00e3o oral para a colite ulcerosa | Universidade de Macau<\/title>\n<meta name=\"description\" content=\"Universidade de Macau: Uma universidade abrangente p\u00fablica de n\u00edvel internacional fundada em 1981\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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