{"id":339717,"date":"2024-05-07T18:04:01","date_gmt":"2024-05-07T10:04:01","guid":{"rendered":"https:\/\/www.um.edu.mo\/news-and-press-releases\/campus-news\/detail\/58287-2\/"},"modified":"2024-05-09T11:37:41","modified_gmt":"2024-05-09T03:37:41","slug":"58287","status":"publish","type":"post","link":"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/campus-news\/detail\/58287\/","title":{"rendered":"UM desenvolve novo medicamento promissor para o tratamento da meningite"},"content":{"rendered":"\n \n

<\/p>

A research team led by Yuan\nZhen, professor in the Faculty of Health Sciences at the University of Macau\n(UM), has developed a new drug capable of effectively treating\nmeningitis. The research results have been published in the internationally\nrenowned journal Science Advances<\/i> and\nhave garnered significant attention in the fields of biology and brain science.<\/p>\n\n

In recent decades, the\nexcessive use of antibiotics has led to the emergence and widespread\ndissemination of multidrug-resistant bacteria, posing a significant challenge\nto public health. Some of these multidrug-resistant bacteria have even been\nclassified by the World Health Organization (WHO) as ESKAPE pathogens, which require\npriority attention. One such pathogen is multidrug-resistant Acinetobacter baumannii<\/i> (A. baumannii<\/i>). At present, antibiotics available\nfor treating A. baumannii<\/i> bacterial\ninfections are limited, with options such as tigecycline and colistin, and the\nemergence of resistant strains to them has been reported. In addition, these\nantibiotics are associated with significant adverse effects, including\nnephrotoxicity. Therefore, there is an urgent need to develop new antibiotics\nto address these issues. Recent studies have focused on the development of\nmetal complexes as novel antibacterial agents against multidrug-resistant\nbacteria. Metal complexes have a distinct three-dimensional arrangement around\none or more metal centres, facilitated by multiple ligands, and exhibit higher bactericidal\nefficacy, greater targeting specificity, and lower resistance.<\/p>\n\n

To eradicate multidrug-resistant\nA. baumannii<\/i>, the research team carried\nout a comprehensive screening of over 1,100 Food and Drug Administration-approved\nsmall molecule drugs and assessed the efficacy of broxyquinoline (Bq) in\ncombination with various metal ions. Among the compounds examined, the research\nteam identified a metal complex called Zn(Bq)2<\/sub>, which proved to be\nan exceptional candidate with an ultra-low minimum inhibitory concentration of\napproximately 0.21\u03bcg\/mL against A.\nbaumannii<\/i>.<\/p>\n\n

Effective antibacterial\nmetal complexes often possess hydrophobicity, which might reduce their\nefficacy. In addition, highly active metal complexes might undergo ligand\nexchange reactions when exposed to different biological environments. To\novercome these limitations and ensure targeted drug delivery and action, the\nresearch team has developed a series of innovative approaches. Firstly, outer\nmembrane vesicles (OMVs) with selective targeting capabilities for A. baumannii<\/i> were genetically engineered.\nThese OMVs can serve as a targeted delivery system to deliver antibacterial\nmetal complexes directly into the target bacteria, thereby enhancing their antibacterial\nefficacy. Secondly, nano-zeolitic imidazolate framework-8 (ZIF-8) was constructed\nas a drug carrier. ZIF-8 enables efficient loading and transport of the potent\nantibacterial metal complex Zn(Bq)2<\/sub>. The use of ZIF-8 enhanced the\nstability and bioavailability of the metal complex and ensured its efficient\ndelivery to the target bacteria. Using these integrated strategies, the\nresearch team achieved a killing efficacy of 99.9999999% against A. baumannii<\/i>. They also established a\nmouse model of A. baumannii<\/i>-induced\nmeningitis and conducted in vivo experiments. The results showed that the\nengineered nanodrug cured A. baumannii<\/i>-induced\nmeningitis, highlighting the drug\u2019s potential to treat bacterial infections, especially\nthose that are difficult to eradicate.<\/p>\n\n

This study not only\naddresses the limitations of traditional antibiotics against A. baumannii<\/i>, but also provides a targeting\nstrategy using genetically engineered OMVs, representing a significant advance\nin the field of targeted bacterial eradication. This antibiotic, which can\neffectively eradicate multidrug-resistant bacteria without causing resistance,\nalso represents a significant advance in the development of non-traditional\nantibiotics and will help combat the growing global threat of antibiotic\nresistance.<\/p>\n\n

The corresponding author\nof this study is Prof Yuan Zhen. His PhD student Wei Xianyuan and former postdoctoral\nfellow Xue Bin are the co-first authors. Ruan Shuangchen, professor at Shenzhen\nPolytechnic University, also provided financial support for the study. The\nresearch project is funded by the Science and Technology Development Fund of the\nMacao SAR (File no: 0020\/2019\/AMJ and 0048\/2021\/AGJ) and UM (File no:\nMYRG2020-00067-FHS, MYRG2019-00082-FHS, MYRG2022-00054-FHS, and\nMYRG-GRG2023-00038-FHS-UMDF). The full version of the research article is\navailable at https:\/\/www.science.org\/doi\/10.1126\/sciadv.adk6331<\/a>.<\/p>\n\n

<\/p>
Source: Faculty of Health Sciences<\/td><\/tr>
<\/td><\/td><\/tr>
Media Contact Information:<\/td><\/tr>
Communications Office, University of Macau<\/td><\/tr>
<\/td><\/td><\/tr>
Albee Lei<\/td>Tel: (853) 8822 8004<\/td><\/tr>
Cravina Chong<\/td>Tel: (853) 8822 4323<\/td><\/tr>
Email:<\/td>prs.media@um.edu.mo<\/a><\/td><\/tr>
<\/td><\/tr><\/tbody><\/table>

<\/p>\n \n ","protected":false},"excerpt":{"rendered":"

A research team led by Yuan Zhen, professor in the Faculty of Health Sciences at the University of Macau (UM), has developed a new drug capable of effectively treating meningitis….<\/p>\n","protected":false},"author":1,"featured_media":339868,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[61],"tags":[],"class_list":["post-339717","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news"],"acf":[],"yoast_head":"\nUM desenvolve novo medicamento promissor para o tratamento da meningite | Universidade de Macau<\/title>\n<meta name=\"description\" content=\"Universidade de Macau: Uma universidade abrangente p\u00fablica de n\u00edvel internacional fundada em 1981\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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