{"id":328470,"date":"2024-01-16T18:04:00","date_gmt":"2024-01-16T10:04:00","guid":{"rendered":"https:\/\/www.um.edu.mo\/news-and-press-releases\/campus-news\/detail\/57538-2\/"},"modified":"2024-01-18T11:22:52","modified_gmt":"2024-01-18T03:22:52","slug":"57538","status":"publish","type":"post","link":"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/campus-news\/detail\/57538\/","title":{"rendered":"UM contribui para o desenvolvimento de medicamentos anticancer\u00edgenos fotossens\u00edveis"},"content":{"rendered":"\n                        \n                        <p>The\nresearch team led by Zhang Xuanjun, associate professor in the Faculty of\nHealth Sciences (FHS) at the University of Macau (UM), has developed a highly effective\nphotosensitive anticancer drug, representing a major breakthrough in the\ndevelopment of practical photosensitive drugs. The drug is not constrained by\noxygen concentration and can effectively address the problem of low efficacy\ncaused by hypoxia in the tumour microenvironment during photodynamic therapy.\nThe research results have been published in the internationally renowned\njournal <i>Nature Communications<\/i>.<\/p><p>Photodynamic\ntherapy (PDT) is a new type of tumour treatment in addition to chemotherapy,\nradiotherapy, surgical treatment, and immunotherapy. Its principle is to use\nphotosensitive drugs to generate toxic reactive oxygen species (ROS) by photochemical\nreactions under laser irradiation, thereby effectively killing tumour cells. It\nhas minimal side effects and is suitable for synergistic treatment. PDT can be divided\ninto Type I and Type II depending on the different ROS produced. The Type-I\npathway generates superoxide anion free radicals, hydroxyl radicals, and\nhydrogen peroxide by electron transfer, while the Type-II mechanism converts\noxygen into singlet oxygen by energy transfer. In clinical practice,\nconventional PDT uses Type-II photosensitisers, which exhibit a disadvantage due\nto their high dependence on the concentration of oxygen during the\nphotochemical process. The hypoxic microenvironment induced by mechanisms such\nas high metabolic rate and high oxygen consumption significantly diminishes the\neffectiveness of PDT. Therefore, the development of hypoxic active Type-I\nphotosensitisers with low oxygen dependence and absorption in the long\nwavelength regions (deeper tissue penetration) is of great significance for\nclinical treatment. However, due to the lack of effective universal design\nstrategies, the development of Type-I photosensitisers lags far behind that of Type-II\nphotosensitisers. Organic iridium (III) complexes are a type of photosensitisers\nwith excellent photocatalytic properties since the bountiful orbits of iridium\natoms can promote the spin-orbit-coupling and lead to a higher probability of\nundergoing intersystem crossing, thus improving Type-I ROS generation. Despite\nthis, their inherent short excitation wavelength results in limited tissue\npenetration and significant photodamage, which has become the main obstacle to their\nclinical application.<\/p><p>The\nresearch team successfully developed a highly effective photosensitive drug by\ntailoring the molecular structures of the selected iridium complexes and\nsemiconducting polymers and assembling them. The drug can not only maintain the\nType-I photochemistry of the iridium complexes, but also take full advantage of\nthe strong absorption of semiconducting polymers in the long-wavelength region.\nWith the incorporation of iridium atoms, the efficiency of metallopolymers in\nROS generation is increased more than 80 times compared with the mother\npolymers. More importantly, this strategy is highly universal and has been\nsuccessfully extended to the development of a series of photosensitive drugs.<\/p><p>The\nnewly developed photosensitive drug has been successfully used in the treatment\nof breast cancer in mice models. The research results were published in <i>Nature\nCommunications<\/i> under the title \u2018Metallopolymer Strategy to Explore Hypoxic\nActive Narrow-Bandgap Photosensitizers for Effective Cancer Photodynamic\nTherapy\u2019.<\/p><p>The\ncorresponding author of the article is Zhang Xuanjun, and the first author is Zhang\nZhao, a PhD graduate of FHS. Yuan Zhen, professor in FHS, Xing Guichuan, professor\nat the Institute of Applied Physics and Materials Engineering of UM, and Wu Changfeng,\nprofessor at Southern University of Science and Technology also made important\ncontributions to the research. The Animal Research Core, the Proteomics,\nMetabolomics and Drug Development Core, and the Biological Imaging and Stem\nCell Core provided high-quality services for the research. The project is supported\nby the Science and Technology Development Fund of the Macao SAR (File no:\n0085\/2020\/A2 and 0114\/2019\/A2), the Guangdong Basic and Applied Basic Research Foundation\n(File no: 2022A151501061 and 2023A1515012524), UM (MYRG2020-00130-FHS and\nMYRG2022-00036-FHS), and the Ministry of Education Frontiers Science Center for\nPrecision Oncology, UM. The full version of the research article can be viewed\nat <a href=\"https:\/\/www.nature.com\/articles\/s41467-023-43890-z\">https:\/\/www.nature.com\/articles\/s41467-023-43890-z<\/a>.<\/p><p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<\/p><p><\/p>\n\n<table style=\"width: 44.7597%;height: 201px\"> <tbody> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 100.095%\" colspan=\"2\">Source: Faculty of Health Sciences<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 100.095%\" colspan=\"2\">Media Contact Information:<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 12px;width: 100.095%\" colspan=\"2\">Communications Office, University of Macau<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Albee Lei<\/td> <td style=\"height: 21px;width: 43.7669%\">Tel: (853) 8822 8004<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Bell Leong<\/td> <td style=\"height: 21px;width: 43.7669%\">Tel: (853) 8822 8009<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Email:<\/td> <td style=\"height: 21px;width: 43.7669%\"><a href=\"mailto:prs.media@um.edu.mo\">prs.media@um.edu.mo<\/a><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"><\/td><td style=\"height: 21px;width: 43.7669%\"><\/td><\/tr>\n<\/tbody>\n<\/table>\n                        \n                        ","protected":false},"excerpt":{"rendered":"<p>The research team led by Zhang Xuanjun, associate professor in the Faculty of Health Sciences (FHS) at the University of Macau (UM), has developed a highly effective photosensitive anticancer drug,&#8230;<\/p>\n","protected":false},"author":1,"featured_media":328805,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[61],"tags":[],"class_list":["post-328470","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>UM contribui para o desenvolvimento de medicamentos anticancer\u00edgenos fotossens\u00edveis | Universidade de Macau<\/title>\n<meta name=\"description\" content=\"Universidade de Macau: Uma universidade abrangente p\u00fablica de 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