{"id":265116,"date":"2022-04-12T08:00:00","date_gmt":"2022-04-11T10:58:00","guid":{"rendered":"https:\/\/www.um.edu.mo\/news-and-press-releases\/campus-news\/detail\/53507-2\/"},"modified":"2022-05-17T12:25:40","modified_gmt":"2022-05-17T04:25:40","slug":"53507","status":"publish","type":"post","link":"https:\/\/www.um.edu.mo\/pt-pt\/news-and-press-releases\/press-release\/detail\/53507\/","title":{"rendered":"UM desenvolve inovadoras nanopart\u00edculas fen\u00f3licas met\u00e1licas para melhorar a efic\u00e1cia terap\u00eautica dos tratamentos do cancro"},"content":{"rendered":"\n                        \n                        <p>A\nresearch team led by Dai Yunlu, assistant professor in the Faculty of Health Sciences\n(FHS), University of Macau (UM), has successfully developed a series of novel\nmetal phenolic nanoparticles to enhance the therapeutic efficacy of various\ncancer treatments. The research findings have been published in the internationally-renowned\njournals <i>Journal of the American\nChemical Society<\/i>, <i>Angewandte Chemie\nInternational Edition<\/i>, <i>Advanced\nFunctional Materials,<\/i> and <i>Nano\nToday<\/i>.\n<\/p><p>&nbsp;<\/p><p>Nanotechnology has seen rapid\ndevelopment in recent years, with multifunctional diagnostic nanocomposites for\ncancer diagnosis, imaging, and treatment being constantly developed and utilised.\nPolyphenolic materials are a class of phenolic\ncompounds with multiple hydroxyl groups, which have excellent properties such\nas good biocompatibility, diverse pharmacological activities, and coordination\nwith metals. In this study, the\nresearch team modified functional molecules (photosensitisers, imaging\nmolecules, and anti-cancer drugs) with polyphenols to develop multi-functional\npolyphenol derivative modules that could provide new therapeutic strategies for\ncancer.<\/p><p>&nbsp;<\/p><p>In the tumour microenvironment, the\ntransitional expression of PD-L1 on the surface of exosomes leads to\nimmunotherapeutic failure. The team constructed phototherapy with metal\nphenolic nanoparticles (PFG), which in combination with photothermal therapy\nand ferroptosis can enhance immunogenic death of tumours and stimulate\nanti-tumour immune effects. PFG has excellent near-infrared II fluorescence and\nphotoacoustic imaging performance, which can be used for precise photothermal\ntherapy, while GW4869 in PFG can effectively inhibit PD-L1 expression in\nexosomes, thus promoting functional T cell proliferation. Considering the\nprecision of the new material with near-infrared II fluorescence, the team has\ndeveloped a metal polyphenol nanosensitizer (Hf-PSP-DTC@PLX) by loading a\nhydrogen sulfide donor with an amphiphilic polymer and chelating a polyphenol\nsemiconductor polymer with hafnium to achieve near-infrared II imaging\nperformance and realize diagnosis and treatment integration. The nanosensitizer produces a reasonable dose\nof hydrogen sulfide, which inhibits mitochondrial respiration and reduces the\noxygen consumption of tumour cells, effectively improving the oxygenation of\ntumour cells.<\/p><p>&nbsp;<\/p><p>Currently, the\napplication of hafnium as a sensitiser for radiotherapy has entered into\nclinical trials, but radiotherapy tolerance is still a problem to be solved.\nIn view of\nthis, the team constructed another hafnium network to achieve a triple kill in tumour\ntherapy, combining radiotherapy, radiodynamic therapy, and immunotherapy.\nThe\nnanoparticles are combined with anti-PD-L1 antibodies to alleviate tumour\ntolerance induced by combination therapy. The nanopump is formed by the\ncoordination of hafnium metal and polyphenol and is embedded with atovaquone\nand sabutoclax to alleviate tumour hypoxia and accelerate apoptosis. Nanopump-encapsulated sabutoclax not only\naccelerates the activation of apoptotic signals but also reduces glutathione\nlevels in the tumour microenvironment. In addition, the team has also developed metal phenolic adjuvants that\ncan effectively lower glutathione levels to enhance acoustic therapy and\nactivate the cGAS-STING pathway in the presence of manganese ions to enhance\nthe immune response in the body and activate cancer immunotherapy. In\nconclusion, the above metal phenolic nanoparticles have broad prospects in &nbsp;precise cancer therapy.<\/p><p>&nbsp;<\/p><p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<\/p><p>Prof Dai Yunlu is the\ncorresponding author of all the studies, and the first authors are FHS\npost-doctoral fellows Xie Lisi and Li Jie as well as doctoral students Sang Wei\nand Tian Hao. All members of Prof Dai\u2019s lab made important contributions to the\nstudies, which are supported by the National Natural Science Foundation of\nChina (File no: 32171318 and 32101069), UM (File no: SRG2018-00130-FHS),\nMinistry of Education Frontiers Science Center for Precision Oncology, the\nScience and Technology Development Fund, Macao SAR (File no: 0109\/2018\/A3,\n0011\/2019\/AKP, 0113\/2019\/A2 and 0103\/2021\/A), and Shenzhen Science and\nTechnology Innovation Commission, Shenzhen-Hong Kong-Macau Science and\nTechnology Plan C (File no: SGDX20201103093600004). The full version of the\nresearch articles can be viewed at: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c09753\">https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c09753<\/a>,&nbsp;<\/p><p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.202200830\">https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.202200830<\/a>,&nbsp;<\/p><p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/adfm.202113168%20\">https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/adfm.202113168<\/a> and <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1748013222000329\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1748013222000329<\/a><\/p><p><\/p><table style=\"width: 44.7597%;height: 201px\"> <tbody> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 100.095%\" colspan=\"2\">Source: Faculty of Health Sciences<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 100.095%\" colspan=\"2\">Media Contact Information:<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 12px;width: 100.095%\" colspan=\"2\">Communications Office, University of Macau<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Albee Lei<\/td> <td style=\"height: 21px;width: 43.7669%\">Tel: (853) 8822 8004<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Cathy Cheang<\/td> <td style=\"height: 21px;width: 43.7669%\">Tel: (853) 8822 8009<\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\">Email:<\/td> <td style=\"height: 21px;width: 43.7669%\"><a href=\"mailto:prs.media@um.edu.mo\">prs.media@um.edu.mo<\/a><\/td>\n<\/tr>\n<tr style=\"height: 21px\">\n<td style=\"height: 21px;width: 56.3278%;min-width: 120px\"> <\/td> <td style=\"height: 21px;width: 43.7669%\"> <\/td> <\/tr> <tr style=\"height: 21px\"> <td style=\"height: 21px;width: 56.3278%;min-width: 120px\"><\/td><td style=\"height: 21px;width: 43.7669%\"><\/td><\/tr>\n<\/tbody>\n<\/table>\n                        \n                        ","protected":false},"excerpt":{"rendered":"<p>A research team led by Dai Yunlu, assistant professor in the Faculty of Health Sciences (FHS), University of Macau (UM), has successfully developed a series of novel metal phenolic nanoparticles&#8230;<\/p>\n","protected":false},"author":1,"featured_media":267492,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[60],"tags":[],"class_list":["post-265116","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>UM desenvolve inovadoras nanopart\u00edculas fen\u00f3licas met\u00e1licas para melhorar a efic\u00e1cia terap\u00eautica dos tratamentos do cancro | Universidade de Macau<\/title>\n<meta name=\"description\" content=\"Universidade de Macau: Uma universidade abrangente p\u00fablica de n\u00edvel internacional fundada em 1981\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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