The State Key Laboratory of Quality Research in Chinese Medicine (QRCM\nLab), Institute of Chinese Medical Sciences (ICMS), University of Macau (UM),\nand the National Cancer Institute (NCI), National Institutes of Health in the\nUnited States, have made significant progress in a collaborative research\nproject on safer and more effective treatment for cancer and autoimmune\ndiseases. The related findings have been published in scientific journals under\nNature <\/i>magazine. <\/p>
Researchers from UM and the NCI established that TNFR2 (tumor necrosis\nfactor receptor 2) plays an important role in the proper functioning and\nproliferation of T cells, especially regulatory T (Treg) cells. This finding\nnot only corrects a theoretical misconception in immunology, but also paves the\nway for developing safer and more effective drugs for tumour and autoimmune\ndiseases.<\/p>
Earlier this month, two papers about the research findings, namely\n\u2018Paradoxical Effects of Targeting TNF Signalling in the Treatment of\nAutoimmunity\u2019, and \u2018TNFR2 Expression by CD4 Effector T Cells Is Required to\nInduce Full-fledged Experimental Colitis\u2019, were published in Nature Reviews Rheumatology<\/i>, and Scientific Reports<\/i>, respectively. UM\nprofessor Chen Xin is the first author and corresponding author of both papers. <\/p>
Since its founding, the QRCM Lab has been committed to nurturing\ncollaboration with internationally renowned institutions in scientific research\nand personnel training. The lab and the NCI have signed a collaboration\nagreement aimed to promote collaboration in studying the mechanism of action of\ntraditional Chinese medicines in regulating the immune system, which has\nproduced many impactful results.<\/p>
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nSo\nfar scientists from UM and the NCI have co-published seven research papers, in Nature Medicine<\/i>, Nature Reviews Rheumatology<\/i>, FASEB\nJournal<\/i>, Journal of Immunology<\/i>, Frontiers in Immunology<\/i>, Scientific Reports<\/i>, and Cellular and Molecular Immunology<\/i>,\nrespectively. More research findings are expected to be published soon. <\/p>
Source: Institute of Chinese Medical Sciences
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