A paper by UM scholars was recently\npublished in Lab on a Chip<\/i>, a\npublication under the Royal Society of Chemistry in the United Kingdom. The\npaper proposes a new technique that can quickly identify the DNA of multiple\npotential pathogens causing septicemia from a single droplet (1uL). This new\ntechnique will allow medical workers to promptly identify pathogens and\nadminister treatment in remote mountainous regions. This is yet another\nbreakthrough in UM\u2019s microchip research. The related system is expected to be\nput into production within the next two years.<\/p>\n\n
Titled \u20183D Microblade Structure for Precise and Parallel Droplet Splitting\non Digital Microfluidic Chips\u2019, the paper was co-written by PhD student Dong\nCheng, Prof Jia Yanwei, Dr Gao Jie, Dr Chen Tianlan, Prof Mak Pui-In, Prof Vai\nMang-I, and Vice Rector (Research) Prof Rui Martins.<\/p>\n\n
In the study, 3D microblades were innovatively fabricated on the pathway\nof droplet transportation on DMF chips, providing precise, reversible, volume\ncontrollable and parallel droplet splitting. With multiple blades implemented,\nonly two electrodes were needed to simultaneously generate up to four daughter\ndroplets in one step splitting. Using this technique, the DNA of multiple\npotential pathogens causing septicemia were successfully identified from a\nsingle droplet (1uL).<\/p>\n\n
According to Prof Jia Yanwei, analysis of parallel DNA is not difficult;\nthe real challenge lies in the volume of the sample. Traditional PCR machines\nnormally require samples of 25uL, and the analysis can only be done in a\nlaboratory. The new technique developed by UM using digital microfluidics only\nrequires a sample of 1uL to achieve the same results. Moreover, this new\ntechnique can be applied to make portable outdoor DNA testing devices. <\/p>\n\n
The main\nadvantage of this system is that it can realise portable DNA testing and\ndiagnose hidden or contagious diseases, which will allow medical workers to\npromptly identify pathogens and administer treatment in remote mountainous\nregions. <\/p>
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Media Contact Information:
Communications Office, University of Macau<\/p>
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Albee Lei Tel\uff1a(853) 88228004
Kelvin U Tel\uff1a(853) 88224322
Email\uff1aprs.media@um.edu.mo
UM Website\uff1awww.umac.mo<\/p><\/div>
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